This chapter presents a case scenario that demonstrates variations in the history and the key features obtained by two different providers evaluating the same patient. It focuses on the initial interaction and interview between each provider and the patient. The chapter then identifies and compares the pertinent pieces of history. The case scenario is about a 67-year-old White male who was recently diagnosed with stage 2 diffuse large B-cell non-Hodgkin’s lymphoma. The chapter reviews the differential diagnosis and then explores final diagnosis which is consistent with cardiac tamponade. Any patient presenting with a chief complaint of shortness of breath must be evaluated, examined, and treated quickly to avoid further distress or cardiorespiratory arrest. Any acute differential diagnosis must be identified or eliminated quickly. To do so, the clinician must ask the necessary questions and perform the exam with this approach in mind.