Evidence-based practice (EBP) is the cornerstone of the doctor of nursing practice’s (DNP’s) role. It represents the practitioners’ commitment to use all means possible to locate the best (most effective) evidence for any given problem and at all points of planning and contact with clients. There are currently over 303 DNP programs nationwide with another 124 programs in the planning stages. With this meteoric rise in programs, it is essential that educational curriculums support DNP students to become EBP leaders and provide the knowledge and skill set needed to translate evidence into practice. EBP is a process that enables clinicians to seek out best practices and determine if and how these practices can be incorporated into patient care. The DNP-prepared nurse is uniquely prepared to synthesize clinical expertise with EBP to improve patient outcomes, provide clinical leadership, and transform healthcare.