Most nurses practice ethics every day without realizing they are applying the concepts of right and wrong to choices in their professional lives. The study of ethics goes beyond the moral sense of right and wrong and is a systematic approach grounded in philosophical principles and theory. To apply ethical reasoning in clinical settings, it is necessary to be able to differentiate among ethics, morality, and the law. Given the complexity and diversity of the environments in which healthcare services are provided, it is important to appropriately apply ethical reasoning and refrain from making decisions solely on the basis of moral beliefs. This chapter helps the reader to define clinical ethics as it applies to the role of the nurses with master’s degrees; differentiate between ethics, morality, and the law; appreciate the role of ethical and legal principles in bioethics; and identify strategies that promote ethical practice.