Since 2000, the number of children and adolescents presenting to the emergency room in psychiatric crisis has nearly doubled, with suicidality among the most common presenting problem. In order to work with this population, it is important to understand the epidemiological trends, prevalence, and incidence rates of child and adolescent suicidality and to identify unique and common risk and protective factors. This chapter addresses these issues, deconstructs myths and misconceptions related to suicide among children and adolescents, and highlights the importance of developmental issues with this population. It also provides an overview of empirically grounded strategies for effective assessment and treatment of this population. Parents have reported that most important to them following their child’s suicide attempt is first keeping their child safe, followed by identifying what caused or triggered the suicide attempt, building strategies to prevent another suicide attempt, and improving communication and building trust for the future.