This chapter appraises the relationship among the personal health record (PHR)/portal, patient engagement/activation, and patient safety and quality. It identifies factors associated with increased patient PHR/portal use. The chapter examines advantages and disadvantages of patient-generated health information. It identifies components of the ideal patient portal, predicts achievable levels of patient engagement/activation in one’s practice, and discusses the model the PHR/portal implementation using the interprofessional approach to increase patient use. The chapter also discusses the rationale for PHRs and associated patient portals is to facilitate the patient’s engagement/activation in the care delivery process. Specifically, patient activation is defined as understanding that one must take charge of one’s health and that actions determine health outcomes, a process of gaining skills, knowledge, and behaviors to manage health and confidence to make needed changes. According to the literature, few studies on measuring the effectiveness of teaching patient portal use have been reported.