This chapter presents a general overview of termination: when to terminate, how to handle the patient who terminates prematurely, under what circumstances the therapist initiates termination, and ethical issues related to termination. It discusses practice guidelines and outcome evaluation in psychotherapy. Evidence-based practice guidelines are essential in order to make conscientious clinical decisions about patients so that appropriate goals can be set, which when met will then determine when to terminate psychotherapy. For cognitive behavioral therapy (CBT), termination begins in the first session and the expected duration is usually discussed at that time when issues and goals for treatment are clarified. Hopefully, educating the person has been part of the therapy all along but reinforcing again is essential during termination. The chapter concludes with a case example illustrating termination and the use of practice guidelines and outcome measures in time-limited psychodynamic psychotherapy.