The manipulation of cerebral laterality is a validated brain-based experimental procedure that can be used to induce rapid changes in emotional states associated with potentially disruptive athlete’s profile (AP) constellations as well as brain hemispheric shifts in the preaction to action transition. Priming or stimulating the right visual and blocking the left visual field using special goggles/glasses is an experimental cerebral laterality manipulation (CLM) intervention that has been associated with demonstrated intervention efficiency and efficacy. CLM manipulation can also be directly applied to facilitate the well-documented pre-action relative to left-to-right hemispheric shifts associated with peak performance responses, especially in athletes who have an ideal AP or more ambiguous hemispheric valence profiles. The manipulation of visual-field input leads to activation of the contralateral brain hemisphere and unequivocal evidence of intervention efficiency that is hard to demonstrate for most mental training modalities.