This chapter traces statistics and trends of the migration of foreign-educated nurses (FENs). It analyzes programs that facilitate adjustment, mentoring, and acculturation of FENs. The chapter develops an educational plan to promote cultural competence among foreign nurses and their employers. It discusses evidence-based practice utilized by receiving institutions to reduce turnover and enhance retention of nurses. The chapter then proposes possible solutions to nurse migration and exodus of nurses from developing countries. There are measures that need to continue to regulate the processes for the benefit of global health, for ensuring quality and standards of nursing care, and for the welfare of FENs themselves. The chapter suggests tapping FENs who have pursued graduate education in Australia, Canada, UK, and the United States to return home for a few months and assist in nursing education, practice, administration, and research in their respective countries.