Cirrhosis, also known as end-stage liver disease, is the final stage of liver fibrosis progression. Cirrhosis can develop for a variety of reasons with the most common causes being alcohol consumption, viral hepatitis, and nonalcoholic steatohepatitis. Management goals are to prevent complications and to preserve quality of life. Cirrhosis is divided into two subsets: compensated and decompensated. There are many nonspecific symptoms that can be associated with cirrhosis, including fatigue, weakness, loss of appetite, and weight loss. Patients with cirrhosis may have abnormal liver function test (LFT) readings, hyperbilirubinemia, elevated international normalized ratio (INR), thrombocytopenia, anemia, leukopenia, hyponatremia, hypoalbuminemia, renal insufficiency, and glucose intolerance. The gold standard for determining the presence and staging of cirrhosis is a liver biopsy. Patients with cirrhosis should undergo screening measures to avoid complications, including regular esophagogastroduodenoscopy (EGD) to appropriately manage varices and prevent bleeding episodes, and imaging studies to rule out hepatocellular carcinoma.