This chapter discusses several case histories, each describing a particular type of epilepsy, such as temporal lobe epilepsy (TLE), frontal lobe epilepsy, limbic encephalitis (LE), status epilepticus, infantile spasms, Lennox-Gastaut syndrome, childhood absence epilepsy, and Rasmussen’s encephalitis. Frontal lobe epilepsy is the most common focal epilepsy after TLE. Patients tend to have stereotyped, hypermotor seizures typically during their sleep that are short-lasting compared to temporal lobe seizures; these are commonly confused with nonepileptic seizures (NES). Treatment of the epilepsy associated with cortical dysplasia is often frustrating, but surgical approaches based on accurately defining epilepto-genic regions are proving increasingly successful. LE is an inflammatory disorder of the limbic system. Two major etiologies of LE are recognized: infectious and autoimmune. In cases of infectious LE, viral agents such as herpes simplex are most often implicated. Autoimmune LE can be further divided into paraneoplastic and nonparaneoplastic forms of the disease.