SITC’s Guide to Managing Immunotherapy Toxicity is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with Anti-CTLA-4 agents, Anti-PD-1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part II concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of ‘financial toxicity’ on patients and caregivers. With chapters written by world-recognized oncology leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists, and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care.
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This book is meant to educate and assist any healthcare professional who has the privilege of caring for patients with acute stroke. Although it is particularly helpful for clinicians who are involved with critical decision making, practitioners at all levels of training can use the book as a guide. The practice of stroke medicine has become quite complex over the past two decades. Fortunately, this is for good reasons. The intricacies associated with management of ischemic and hemorrhagic strokes reflect improved understanding of the disease process, advances in neuroimaging, and development of novel treatment options. In the first 24 to 72 hours of hospitalization, stroke patients are susceptible to a whole host of cerebral (neurological) and extracerebral (medical) complications. Being familiar with these complications and having the knowledge to properly identify and manage them can reduce length of hospital stay, adverse functional outcomes, and mortality. This book hopes that practitioners will appreciate acute stroke management as a dynamic process and understand the uniqueness of acute stroke as a clinical entity with its potential for complications that may be a direct or indirect consequence of the initial brain injury. The book consists of fifteen chapters. Chapter one provides an introduction to complications of acute stroke. Chapter two discusses cerebral ischemic infarction. Next three chapters focus on expansion of intracerebral hemorrhage; cerebral edema in stroke; and post-thrombolysis hemorrhage and hemorrhagic transformation of cerebral infarction. Chapters six and seven discuss endovascular and postprocedural complications and reperfusion injury in ischemic stroke. The next two chapters focus on stroke-related seizures, rebleeding, vasospasm, and hydrocephalus after subarachnoid Hemorrhage. Chapter ten describes the complications of cerebral venous thrombosis. The following four chapters discuss complications after stroke such as delirium, cardiac complications, pulmonary complications, and metabolic complications. The last chapter briefly describes poststroke infections.
This book provides a practical and concise text for electromyography (
EMG) rotations and is a great companion to the larger reference texts that successful electrodiagnosticians also need. It provides more of the practical information on EMGsthat made the first edition so successful. In addition, it includes pictures, text, clinical pearls, questions, and tables and provided novel chapters such as the use of ultrasound in electrodiagnostics. These chapters are written by some of the foremost and experienced authorities in the field. This book includes 35 chapters. These chapters are organized into six sections. Section I consists of Chapters 1–3. It provides introduction to electrodiagnosis, instrumentation and systematic approach to learning and performing nerve conduction studies. Section II consists of Chapters 4–9. It discusses motor and sensory studies of upper limb and lower limb. Section II also discusses the F-waves and H-reflexes. Section III consists of Chapters 10–13. It provides basic approach to EMGtechnique and waveform recognition. Section III also describes motor unit action potential analysis and recruitment. Section IV consists of Chapters 14–17. It discusses orthodromic and antidromic nerve conduction studies; temporal dispersion and phase cancellation; interpreting studies; and common anomalies. Section V consists of Chapters 18–33. It discusses carpal tunnel syndrome; neuropathy of ulnar and radial; anterior interosseous nerve lesion; fibular and tibial neuropathy; lumbosacral and cervical radiculopathy; facial nerve and blink studies; repetitive stimulation and neuromuscular junction disorders; peripheral neuropathy; brachial plexopathy; motor neuron disease; myopathy; and the use of ultrasound with electrodiagnosis. Section VI includes Chapters 34 and 35 which include study checklists and the answers to the multiple choice questions located within the chapters.
This book is the essential quick reference for medical students, residents, and attending physicians in the field of physical medicine and rehabilitation. The third edition of the book expands upon the first two editions, with new evidence-based data and updated references on topics relevant to the field of physical medicine and rehabilitation. It is crammed with useful tables, charts, illustrations, and clinical tips and guidelines for effective patient care and restoration of function. The book covers around 33 topics. The entries include neurologic examination, gait and gait aids, wheelchairs, modalities, therapeutic exercise, acupuncture, amputation/prosthetics, pediatrics - cerebral palsy, concussion, pain medicine, musculoskeletal/sports/orthopedics, ultrasound, electrodiagnostic studies, cardiac rehabilitation, pulmonary rehabilitation, burn rehabilitation, cancer rehabilitation, spinal cord injury, traumatic brain injury, stroke, physiological changes with aging, rheumatology, osteoporosis, multiple sclerosis, movement disorders, acute inflammatory demyelinating polyneuropathy, spasticity, neurogenic bladder, language, speech, and swallowing, heterotopic ossification, deep venous thrombosis, pressure injury, and quality improvement.
Diagnostic and interventional sonography has become an important clinical tool for physicians treating musculoskeletal conditions. Sonography is a very useful tool for those that desire to fill out and test the differential diagnosis that is created with history and physical examination. Learners often lack understanding of spatial relationships within an anatomic region. They need to develop visual acuity to cross-sectional anatomy. This book presents cross-sectional sonographic images to promote a better understanding of clinical anatomy. Each image is accompanied by an illustration that serves as a road map to the image and highlights important structures. Both image and illustration make apparent the dynamic nature of these anatomic relationships. One of the first things taught in training sonographers is the echogenic appearance of various tissues. This pattern recognition is critical to deciphering a sonographic image. The book expands that pattern recognition to include all of the tissues in a cross sectional image and each accompanying illustration provides a visual translation of the sonograph. The cross-sectional images highlight important aspects of an anatomical region. There are also selected extended field of view images along the long axis of a structure to add another dimension to the area of study. The book identifies cross sections of each segment of the upper extremity and lower extremity that are important to understand as visual touchstones for anyone performing diagnostic sonography. Each is placed alongside an illustration that documents the structures in the sonograph. There is also legend for every image/illustration couplet that allows the user to identify individual structures in each. There is a body icon with the cursor in the location of each image/illustration couplet to help the reader localize the position of each sonograph. The book also provides a few images of pathology that demonstrate how pathology is represented in a sonograph.
From its initial ophthalmologic indications, the number of approved, accepted, and proposed uses for botulinum neurotoxin (
BoNT) therapy has expanded to include a large number of applications for various body systems. At the same time, developments in the field of ultrasound ( US) including high frequency linear transducers technology have led to the rapid expansion of USfor both diagnostic imaging and procedural guidance. Physicians who perform chemodenervation procedures have long recognized the limitations of standard techniques used to localize muscles or nerves. This has led an increasing numbers of physicians to explore and promote USimaging as a practical and more accurate alternative guidance technique for these procedures. Although there numerous texts and atlases specific to the subject of musculoskeletal ultrasound and for the subject of neurotoxin therapy/chemodenervation, there is limited reference material for physicians on ultrasound guidance for chemodenervation including neurotoxin therapy. The purpose of this Atlas is to provide a review of neurotoxin therapy with a strong emphasis on ultrasound technology and its applications for chemodenervation. The authors hope the material presented in this text/ DVDwill reduce at least one barrier that physicians encounter when trying to add US-guided chemodenervation procedures in the clinic. The text section of the book provides an introduction or review of UStechnology, scanning techniques and image optimization required for US-guided neurotoxin/chemodenervation. The illustrated print and DVDAtlas sections serve as a reference manual for physicians to be used during US-guided chemodenervation procedures. The authors hope the material provided in this multimedia text will serve to educate clinicians, expand their knowledge of USand chemodenervation focused on BoNTtherapy and reduce the risks inherent in these procedures and enhance patient care.
The purpose of this handbook is to create a practical guide for trainees, nurse practitioners, physician assistants, and attending physicians to guide them in the treatment of patients with gastrointestinal cancers. The handbook provides key information on diagnosis and treatment, while highlighting the epidemiology, molecular data, and additionally various multimodality treatment options for a broad array of gastrointestinal cancers. It is concise and easy to read, yet broad and practical in its ability to provide for the needs of the medical professional dealing with gastrointestinal cancers. Unique to the book are “How I Treat” vignettes providing not only standards of care but expert recommendations for approaching tough-to-treat disease sites and, in some cases, rare or uncommon patient scenarios. The book is appropriate for physicians in all specialties as well as primary care physicians and other healthcare professionals who are essential members of any team caring for the patient with gastrointestinal cancer. It begins with the most common of the gastrointestinal cancers, colon and rectal cancer, followed by pancreatic, hepatocellular, esophageal, and gastric cancer, cancer of the bile ducts and gallbladder, and then the more rare and unusual cancers such as gastrointestinal stromal tumors, neuroendocrine tumors, and anal carcinoma. In each of these sections, the authors use evidence-based guidelines for the specific cancer to focus on epidemiology and biologic aspects of the disease, including genetic factors and molecular biology. Chapters also discuss modifiable factors, diagnostic testing, and techniques consisting of the molecular basis of diagnosis and treatment of early and advanced disease, which incorporates the role of surgery, neoadjuvant and adjuvant chemotherapy, radiation therapy, immunotherapy, and biologics and their selection and ablative techniques. The presentation is very helpful and unique in that the authors approach advanced disease as oligometastatic and widely metastatic and account for how these approaches differ.
The goal of the electromyographer is to localize lesions and to characterize them. In order to accomplish these goals, a minimum core of knowledge in neuroscience is required. This book discusses that core of neuroscientific knowledge as a stepping stone to lesion localization and characterization. Following this, it demonstrates how this information is actually utilized in the electromyography (
EMG) laboratory using a case study approach. Although several excellent EMGcase study-based textbooks are available, the book is unique in that it offers a step-by-step analysis of the nerve conduction studies ( NCS) and needle EMGstudies as they are collected, including a discussion of the initial studies required based on the presenting clinical features, an interpretation of those initial studies, and the indications for subsequent studies based on that interpretation. This step-by-step analysis continues until the lesion has been fully localized and characterized. The book is extensive and explains the important principles and concepts underlying electrodiagnosis ( EDX) medicine. It reviews the anatomy and physiology of the peripheral neuromuscular system, basic principles of NCS, specific concepts pertinent to each type of NCS(motor, sensory, and mixed NCS, as well as repetitive nerve stimulation studies), and the basic principles of needle EMG. Following this, it discusses the NCSand needle EMGmeasurements made, their meaning, and the EDXmanifestations of the various neuromuscular disorders. It also includes a discussion of the various types of nerve injuries and a review of reinnervation. It focuses on lesion localization and the characterization of the lesion, including its pathology, pathophysiology, severity, and temporal features. The book demonstrates the application of the principles and concepts through 60 EDXcase studies collected from the authors' EMGlaboratories using a step-by-step analysis format.
Home Exercise Programs for Musculoskeletal and Sports Injuries:The Evidence-Based Guide for Practitioners
This book is designed to assist and guide healthcare professionals in prescribing home exercise programs in an efficient and easy to follow format. With patient handouts that are comprehensive and customizable, this manual is intended for the busy practitioner in any medical specialty who prescribes exercise for musculoskeletal injuries and conditions.
The most central aspect of any therapeutic exercise program is the patient’s ability to perform the exercises effectively and routinely at home. This book is organized by major body regions from neck to foot and covers the breadth of home exercises for problems in each area based on the current literature. Each chapter begins with a brief introduction to the rehabilitation issues surrounding the types of injuries that can occur and general exercise objectives with desired outcomes, followed by a concise review of the specific conditions and a list of recommended exercises. The remainder of the chapter is a visual presentation of the exercises with high-quality photographs and step-by-step instructions for performing them accurately. The most fundamental exercises to the rehabilitation of each specific region are presented first as the essential building blocks, followed then by condition-specific exercises that advance throughout the chapter. Using this section, the healthcare practitioner can provide patients with handouts that require little to no explanation and can customize the program and modify instructions to fit individual patient needs and abilities—with confidence the handouts will be a valuable tool to help patients recover successfully from musculoskeletal and sports injuries.