This chapter begins with a description of multiple systematic reviews and meta analyses of problem-solving therapy (PST) interventions. The number of studies evaluating PST has increased over the past decade, so more reviews has been conducted. The chapter discusses PST for various mental and physical health problems and depression. Following this it also discusses PST in primary care and among older adults. It briefly describes PST for diabetes self-management and control; vision-impaired adults and social problem-solving therapy in school settings. The chapter describes PST as a transdiagnostic approach. It briefs the listing of PST investigations and supports the characterization of this approach as a transdiagnostic intervention. The chapter also demonstrates its flexibility of applications. Finally, it highlights certain aspects of the recent outcome literature featuring various clinical problems (e.g., health and behavioral health disorders), populations (e.g., older adults, children, ethnic minorities), and modes of delivery (e.g., telehealth).