Genitourinary cancers include cancers of the urinary tract (prostate, bladder, urethra, and kidney) and the male genital tract (testis and penis). This chapter briefly discusses the epidemiology, diagnosis, treatment, and the rehab perspective of prostate cancer, carcinoma of the bladder and the upper urogenital tract, testis cancer, renal cell carcinoma, and penile cancer. Patients with prostate cancer now live longer with their metastatic disease and pose greater challenges for rehabilitation physicians. Bladder cancer most commonly presents with total (present throughout the length of micturition) gross painless hematuria. Radical orchiectomy through the inguinal approach is required for diagnosis and staging of testis cancer. Carcinoma of the penis comprises less than 1% of all malignancies in men. Predisposing factors include the presence of foreskin, and human papillomavirus exposure. The treatment recommendation for this rare disease is by stage. Penile conservation surgical techniques can include laser, Mohs surgery, and partial penectomy when feasible.