Assessment of the face, nose, and throat is an essential skill for the pediatric healthcare provider. Upper respiratory infections, allergies, oral or facial trauma, dental caries, and pharyngitis are common diagnoses in children. When obtaining the history and physical examination of the face, nose, and throat in children, the healthcare provider can also identify parent and child teaching opportunities, for example, encouraging regular dental care, compliance with antibiotic therapy for streptococcal pharyngitis, and the consistent use of sports safety gear to avoid oral and facial injuries. As part of the assessment of the face, nose, and mouth, the quality of the child's speech is also evaluated. Appropriate referrals to a speech pathologist, otolaryngologist, and pediatric dentist may be necessary. Various diagnostic tests may be necessary to clarify differential diagnoses of abnormal conditions involving the face, nose, and mouth. This chapter summarizes some examples of these diagnostic studies and their indications.