Congenital diaphragmatic hernia (CDH), a major congenital defect, occurs in 3.3–5 per 10,000 live births. It is associated with significant morbidity and mortality risks, with lifelong implications imposed on survivors. The pathophysiology, diagnostic tools, and treatment modalities for CDH must be understood to provide timely, holistic care to the infant and family. Swanson’s theory of caring can effectively guide the interprofessional perinatal/neonatal team in the prenatal and postnatal care of the infant and family.