This chapter outlines the basic information for assessing, managing, and discharging the normal newborn. There is growing evidence to support the need for neonatal nurses to have a better understanding of the normal newborn as they care for the sick and/or preterm infant. The nurse caring for the newborn plays a unique role in not only providing care to the newborn but also in assisting in the integration of the baby into the family. Understanding of the newborn is optimized when information related to the mother and family is known. The information from the maternal history, which includes previous health issues, prenatal, intrapartum, and postpartum histories, is critical for assessing adaptation to extrauterine life. This information gives insight into the environment from which the newborn has come and therefore helps determine the nurse’s plan of care.