Working in healthcare is extremely rewarding but also presents many challenges that can lead to burnout. Building resilience is critical for sustaining a lifelong, rewarding career in nursing. Resilience is a personality trait that enables one to overcome challenges and resolve negative emotions. Through a combination of consistent use of self-care techniques and engaging in workplace initiatives to decrease stress and foster a positive work environment, nurses can reduce their risk of burnout and other work-related issues. Self-care helps nurses to consistently deliver quality patient care over the course of their careers. To cope with the numerous pressures of nursing work, nurses must find ways to release negative emotions, deal with conflict, and promote their own well-being. This chapter discusses ways to build resilience, cope with multiple patient losses, and employ self-care practices.