This chapter defines new meaning to nursing’s paradigm that were derived from clinically inducted, empirical experiences, combined with the authors’ philosophical, intellectual, and experiential background. The early work emerged from the authors’ own values, beliefs, and perceptions about personhood, life, health, and healing, and how they manifest clinically and empirically. The authors’ work was guided by the commitment to nursing’s collective caring-healing role and mission in society as attending to and helping to sustain humanity and wholeness as foundation to health and nursing’s purpose for existence. The original work was further shaped by phenomenological psychology and philosophy. The cara-tive factors and general caring language help to release nursing from its political and practice history of medical language dominance and orientation. The carative factors thus serve to help define nursing knowledge, practices, and phenomena as distinct from, but complementary with, curing knowledge and practices associated with modern medicine.