This chapter describes a brief history of person-centered care (PCC) and identifies the characteristics of PCC. It discusses the importance of organizational structure to support PCC and effective communication. It then articulates the way in which psychosocial factors affect patient decision-making and clinical outcomes. The chapter lists the strategies to support patients’ and caregivers’ engagement in their care. It discusses the importance of constructing a PCC plan for patients with physical illness and injury that incorporates psychosocial factors and the Social Determinants of Health (SDoH). It also discusses discharge planning as a means of ensuring continuity of care, and describes the use of shared decision-making techniques and patient decision aids to encourage PCC. The chapter focuses on strategies and practices that support a broad definition of PCC with the goal of improving patient safety and the quality of patient care, while providing strategies to help reduce barriers to PCC implementation.