Psychologically, individuals must learn to cope with a sudden and often unexpected change in physical function that frequently results in at least an initial dependence on others for most of the basic needs. This chapter reviews frequently experienced psychosocial factors post-spinal cord injury (SCI), such as psychopathology, issues related to sexuality and social relationships, as well as positive factors. It is critically important to recognize that these issues must be examined within the context of each individual person with SCI and may or may not be applicable based on that individual's premorbid history, cultural identity, coping skills, and degree of social support. The chapter covers four mental health disorders as well as pain, a common secondary condition of SCI. The four mental health disorders are depression, anxiety, and trauma- and stressor-related disorders. The chapter highlights various psychosocial issues that are important to consider throughout inpatient SCI rehabilitation and outpatient follow-up.