Of all emergencies, respiratory problems must be treated first. Without a patent airway and breathing, a patient will die-and nothing else matters. Emergency nurses must be able to recognize and rapidly respond to any respiratory emergency. This chapter reviews the most common respiratory conditions seen in the emergency department (ED), discussing causes, signs and symptoms, and interventions for conditions such as acute respiratory distress syndrome, airway obstructions, chronic obstructive pulmonary disease, status asthmaticus, spontaneous pneumothorax, pneumonia, and burn inhalation. The chapter also includes a section on assisting with drug-assisted intubation or rapid sequence intubation. When dealing with respiratory emergencies, be sure to thoroughly document respiratory assessments, including rate, depth, breath sounds, symmetry, skin color, use of accessory muscles (if labored or unlabored), and ability to speak in full sentences before and after each intervention.