Parenting and normal parental attachment begin not at birth, but before and during pregnancy. The increase of maternal hormones during pregnancy helps with the formation of maternal bonding. After birth, the interaction between mother/father and their baby helps to build strong parental attachment and bonding. Family-centered care (FCC) principles stress that parents are the most important person in their infant’s life, that they have expertise in caring for the infant, and that their values and beliefs should be central during NICU care. The use of FCC has been shown to enhance the likelihood of successful parent–child relationships. Having a sick/premature infant who requires neonatal intensive care can initiate many different emotions in parents. These include but are not limited to stress, guilt, anxiety, and fear. Healthcare professionals can help parents with these emotions by listening, giving honest, accurate, and consistent information and continually assessing parents understanding of their infant’s condition.