The prevalence of depression, burnout, suicidal intent, and chronic health conditions is higher in healthcare clinicians than in the general population. Pediatric clinicians face unique challenges when delivering patient care due to the complexity of the family dynamics and the special needs of caring for an ill child. Burnout consists of emotional exhaustion, no longer finding work meaningful, feeling ineffective, and a tendency to view patients, students, and colleagues as objects rather than as human beings. Conditions associated with burnout include headaches, tension, insomnia, fatigue, anger, impaired memory, decreased attention, thoughts of quitting work, drug and alcohol use, and suicide. Burnout not only has adverse effects on clinician population health and healthcare quality and healthcare safety, but it contributes to high turnover and substantial financial losses. Good self-care by pediatric clinicians and systems that support clinician wellness are imperative to prevent burnout, compassion fatigue, and other mental health disorders.