This chapter briefly describes palliative and end-of-life care, benefits of palliative care, and the role of palliative social workers. The aim of palliative care is to improve quality of life for the patient and family. Palliative care specialists facilitate communication among the patient, healthcare providers, and family members to better understand the illness and goals of care. Palliative care is delivered in a wide range of settings and with different models of care. These settings include: inpatient facilities, including intensive care units (ICUs), emergency departments, outpatient settings, community-based settings, long-term care facilities, and home-based settings. Palliative care is a deeply rewarding practice area because it involves developing and using advanced clinical skills, is stimulating and challenging, involves interdisciplinary collaboration, and, most importantly, offers the opportunity for making a very meaningful contribution to patients and family members as they experience one of the most important transitions in their lives.