This chapter provides an overview of the salient psychosocial aspects of chronic illness and disability. It reviews the models of chronic illness and disability; psychosocial, environmental, and attitudinal aspects of chronic illness and disability; culture, chronic illness, and disability; adjustment to disability models and concepts; and sexuality, gender identity, chronic illness, and disability. In addition, the chapter provides readers with an in-depth review of specific psychological constructs relevant to living with a chronic illness and disability as well as social factors that encompass a wide array of interpersonal, environmental, and attitudinal factors, such as social support, access, accommodations, and ableism. The chapter also discusses how culture influences the experience of living with chronic illness and disability, reminding readers to consider the individual’s cultural factors and the impact of both their culture and Western culture on their experience.