Each individual is complex, and, as such, is an integral part of many distinct populations or groups. Such groups can be categorized based on the geographical location where people reside or by more specific personal information such as gender, age, race, ethnicity, socioeconomic status, or presence of a specific diagnosis or health condition. Unlike traditional textbooks that begin with extensive reviews of historical facts and gradually develop topics over several chapters, this book aims to prepare nurses and student nurses for practical, evidence-based application from page one. It is divided into five overarching sections, each exploring population health in the following settings: community based; home care and rural; school-based and primary care; medical homes and palliative care; and acute and long-term care. Sections begin with an overview chapter introducing readers to fundamental concepts about the setting and groups served therein, including characteristic trends, expenditures, and critical concepts. Overview chapters are followed by more succinct chapters highlighting specific populations across the life span and the diseases, illnesses, or healthy/risky behaviors common to them. Chapter topics include nurse advocacy and policy roles; care access; emergency preparedness; community resiliency; infectious and chronic disease prevention, care, and outcomes; obesity, addiction, alcohol use, and anxiety disorders; perinatal death; medication management; and emergency department use and misuse. Chapters include populations living at home, in rural settings, or on college campuses; the homeless, Veteran, and immigrant populations; and those utilizing primary care offices, medical homes, and acute and long-term care facilities. Strategies, resources, and data are used to exemplify the nursing role when caring for individual people who compose larger populations with similar outcomes. Chapters conclude with case studies written from the nurse’s perspective in each setting. Sample questions and answers with rationale are provided to help the reader integrate the information learned into practical application.