The field of infectious disease epidemiology has been front-and-center for the past few years. It has its own unique culture and set of tools and rules. This book offers a whole new vocabulary, from how to consider transmission—with the idea of a disease reproductive rate—to how disease is dispersed or clustered, and how to design a study. It presents the key concepts and principles underlying infectious disease epidemiology in an organized manner, and describes important activities such as disease surveillance and outbreak investigation. The book is valuable to those beginning their study of infectious disease epidemiology, as well as those working to train the next generation of prevention and control experts. It provides a unique introduction and perspective to the field of infectious disease epidemiology, utilizing a combination of intuitive case studies, popular media examples, and didactic exercises. The chapters introduce learners to major conceptual approaches in the field, as well as key factors that enable us to mitigate disease spread. Each chapter is structured to include key terms, a helpful narrative, “Heads Up” sections that help to allay conceptual confusion, highlights on a key figure in history, and a section with lessons learned from the classroom and questions to foster further investigation. The book is structured into four parts that walk learners through the world of infectious disease epidemiology, first covering disease emergence and basics, moving on to modes of transmission and types of diseases, then proceeding to infectious diseases in context, and finally disease control, eradication, and emergence. The authors hope that both the integrated approach and content of the book provide an exciting entrée into a field that is rich in its complexity, dynamicism, and multidisciplinary leanings.