This book provides a state-of-the-art overview of the principles of cancer care and best practices for restoring function and quality of life to cancer survivors. Cancer rehabilitation interventions including physical, occupational, or speech therapy; exercise training; psychosocial and cognitive interventions; and physician-directed diagnostic imaging, injections, and pharmacologic symptom management have the potential to treat many impairments from cancer treatment, thereby improving functioning and quality of life. Multimodal rehabilitation interventions have also been shown to improve return to work compared to usual care. The chapters of the book review the latest evidence about which interventions should be used to treat specific impairments thereby constituting the most comprehensive and up-to-date reference on this topic. The book is organized into nine parts comprising 90 chapters. Part one presents history of cancer rehabilitation, cancer statistics, and principles of cancer care. Part two discusses various cancer types, which includes breast cancer, gastrointestinal malignancies, head and neck cancer, pediatric cancers, and primary bone tumors and their assessment and management. Parts three through six describe cancer pain, medical complications, neurological and neuromuscular complications, and musculoskeletal complications of cancer such as radiculopathy, plexopathy, autonomic dysfunction, and bone metastases and their management. Part seven discusses general topics related to cancer rehabilitation, which includes physical and occupational therapy, therapeutic modalities in cancer, therapeutic exercise in cancer, nutritional care of the cancer patient, sexuality issues, and distress and other psychiatric considerations in cancer rehabilitation. Part eight thoroughly explores the identification, evaluation, and treatment of specific impairments and disabilities that result from cancer and the treatment of cancer such as balance and gait dysfunction, cancer related fatigue, radiation fibrosis syndrome, and bowel dysfunction. Part nine discusses functional measurement in patients with cancer, health maintenance and screening in cancer survivors, research issues, barriers to accessing cancer rehabilitation, and building a cancer rehabilitation program.

Preparation for board examinations can be a daunting and an overwhelming process for many of us. Trainees are often busy with research projects, manuscripts, and a large clinical volume, making it difficult to find time to study for board examinations. Practicing physicians find it hard to keep up on material needed for board recertification. Questions on the board examinations are drawn from well-established, validated medical literature and widely accepted clinical guidelines. This book provides a comprehensive overview of the field of radiation oncology. The format has been designed to efficiently test and reinforce knowledge of key concepts, critical studies, and major clinical guidelines, with the most important radiation oncology citations included. From trainees preparing for their board exams to practicing physicians looking for a review or preparing for the maintenance of certification exam, whether it be a few minutes between patients or a dedicated study session, the book will an invaluable resource to the radiation oncology community. The book is organized into ten chapters. It covers oncology topics such as head and neck cancers, central nervous system cancers, breast cancer, thoracic cancers, gastrointestinal cancers, genitourinary cancers, gynecologic cancers, lymphomas, soft tissue sarcoma, and pediatric cancers. Each chapter has detailed questions covering natural history, epidemiology, diagnosis, staging, treatment options, and treatment-related side effects all in a newly configured format.

This revised and updated second edition of Handbook of Hematologic Malignancies continues to be an essential and “go-to” resource for the busy hematologist, hematologic oncologist, hematopathologist, oncology advanced practice provider, oncology nurse, and trainee. Hematologic malignancies and their treatment have witnessed many changes in this past decade. Innovations from improved diagnostics to therapeutics have reshaped the ways in which these diseases are characterized and managed. This book highlights critical differential diagnoses to consider as well as provides the most current prognostication tables for each disease in order to facilitate direct extension of this information to the patients. In addition, it includes full-color pathology images that have been selected for their exceptional clarity to help the reader elucidate subtle morphologic differences between disease entities. Concisely organized, each chapter provides the most current, need-to-know points of diagnosis, prognosis, therapeutic management, and clinical trial opportunities for each hematological malignancy. The authors have created relevant clinical cases not only in the book but also in accessible online cases, supporting each chapter with corresponding questions to highlight important deliverables from every chapter. The book provides evidence-based algorithms guiding treatment recommendations for both frontline and salvage settings, with key references supporting each recommendation. The authors’ intention was to create a reference textbook that is concise and easy to read, serving the needs of the medical professional dealing with hematologic malignancies. They highlight current clinical trials that may alter our future practice decisions. Notably, in this 2nd edition, they not only provide major updates and insight into future practice-changing clinical trials but add numerous chapters, particularly those focused on novel cellular immunotherapy, which has been the most exciting revolution in the clinical care of patients with hematologic malignancies.

This second edition of Pocket Guide to Radiation Oncology provides an updated and rapid review of the existing standard of care and the most relevant literature. Like the first edition, this quick pocket-sized reference can be carried for a quick review instead of heavy textbooks often filled with esoteric topics and lengthy minutiae. The book has new chapters on the growing areas of oligometastatic disease, benign indications, and proton therapy. The book comprises 55 chapters organized by site-specific diseases: central nervous system neoplasms, head and neck cancers, thoracic cancers, breast cancer, gastrointestinal cancers, gynecologic cancers, genitourinary cancers, lymphoma, sarcoma, skin cancers, pediatric malignancies, metastatic disease, and benign indications. The chapters present must-know key points, including treatment options by stage, technical considerations, and important items for follow-up. Clinical pearls and tables covering treatment options, dose constraints, side effects, target delineations, and treatment planning complete each chapter. The chapters conclude with a list of selected, summarized studies relevant to the disease. The book takes an efficient and no-frills approach to fundamental topics in the field, making it the perfect reference for a quick review for the board exam or MOC and even serving as a handy reference during a case review at a tumor board. The book provides essential, quick reference appendices on radiation therapy symptom management, normal tissue tolerance constraints, and radiation therapy and new systemic agents.

The revolution in molecular technology that began in the late 1980s is now being brought to bear on the structural design of agents that selectively target tumor-related gene mutations and signaling pathway intermediaries in ways that may augment tumor cell death and spare underlying normal cell populations. This book embodies all principles of bidirectional translational research, moving basic laboratory science into patients and, at the same time, moving clinical observations into the laboratory to achieve an optimal clinical outcome. It provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, the book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon malignancies. Beautifully illustrated throughout, each chapter contains visually engaging figures detailing the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic, and molecular properties of the various agents, and their mechanisms of action. As the first illustrated book of its kind, this highly visual text uses a uniform approach to each cancer drug class and agent presented in the book, and covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Flow diagrams, clinical tables, and bulleted text further explain important information pertaining to each cancer drug class including their indications, mechanisms of action, potential adverse reactions, dosing and dose adjustments, and safety monitoring. Organized in an easy-to-digest format and replete with detailed images, clinical pearls, and end of chapter Q&As, this evidence-based reference presents all major classes, agents, targets, and approaches to cancer pharmacotherapy.

This handbook is structured to provide comprehensive care for the gynecologic cancer patient. It is directed toward clinicians at all levels of training and the chapters are tiered in this fashion. It outlines the basic diagnosis, workup, staging, and treatment. The book recommends specific surgical and adjuvant therapies that reflect the most current standards of care. Finally, it summarizes the evidence-based medicine in support of recommended treatments. Thus, the medical student can have a dedicated overview, the resident can refer to directed patient-care protocols, and the fellow and practicing physician can support their clinical decisions with easily accessible literature. The updated third edition furthers the content to include the latest cancer-screening information, new surgical technology and platforms, novel cytotoxic chemotherapy, in addition to targeted and immunotherapy treatments, vaccination information, and the most current clinical trial outcomes. The ninth edition AJCC staging guidelines have also been incorporated, providing accurate instructions for staging to keep the reader at the forefront of medicine. With this additional information, the authors continue to provide a comprehensive and contemporary reference for clinical practice. This book again acknowledges the dedication it has taken from the physicians, support staff, and especially our patients, to design and participate in the trials that have advanced the knowledge of these difficult gynecologic cancers. The authors hope the information provided herein can continue to guide high-quality care and reflect the commitment to the subspecialty.

This book attempts to build students’ understanding of policy development through a critical analysis and review of policy frameworks, and the policy implementation process. The book is organized into four parts comprising twenty-one chapters. Part one of this book lays out a background as to the current and future demographic trends of older adults and makes the case for the reader that there are a variety of philosophical, political, economic, and social factors that affect public policy development. The chapters help the reader to explore a range of perspectives that define, shape, and impact the development and implementation of public policy. It intends to prepare the reader to critically analyze public policies related to aging. Part two provides an overview to major federal policies and programs that impact older adults and people with disabilities. It examines some historical developments leading up to the actual development and implementation of the policies. Policies include social security, medicare, the Older Americans Act, and the Americans with Disabilities Act, the Community Mental Health Centers Act, and Freedom Initiative. The last part of the book outlines specific programmatic areas that flow from aging policies, and specific components that flow from federally mandated policies. Each chapter contains same basic outline: an overview of the programs, specific features and strengths of the programs, gaps and areas for development, and challenges for the future.

The field of stem cell transplantation has evolved dramatically over the past decade. Improvements in supportive care and the use of targeted therapies after transplant to prevent relapse have improved the outcome for patients undergoing autologous transplantation. This modality of therapy remains an important therapeutic option for patients with myeloma and relapsed lymphoma. The limitations of donor availability for allogeneic transplant has been largely eliminated with improved molecular typing for unrelated donors and the increasing use of alternative donor stem cell sources, such as haploidentical donors and umbilical cord blood. The safety of allogeneic transplantation has improved by the routine assessment of a patient’s comorbidities and the tailoring of the transplant intensity to achieve the best outcome. This handbook discusses a number of diseases in detail. The chapters give the reader an increased understanding of the disease and the options for therapy. It also allows the reader to understand the role of either transplantation or cellular therapy in the context of disease risk and other therapeutic options. The handbook provides a resource to clinicians caring for patients undergoing transplantation or receiving cellular therapies. Fellows, interns, residents, students, advanced practice professionals in nursing and physician assistants, and pharmacists, as well as others in the care of these patients, may find this handbook useful. The book describes the role of transplantation or cellular therapies in a variety of hematologic malignancies. There are chapters addressing complications related to infections, liver dysfunction, renal dysfunction and pulmonary complications. Special emphasis is given to both acute and chronic graft-versus-host disease and their management. Finally, there is an important chapter on the long-term management of patients after transplantation, which should be of help to all providers who care for survivors of transplantation.

Head and neck cancers are challenging diseases that require complex management and exemplify the value of collaboration among multiple specialties. Very appropriately, the Editors are representatives of each of the three major treatment modalities. The genesis of this work was driven by recognition that, despite evolution in various approaches and new emerging data, high quality clinical care is optimal when there is mutual respect of each other’s discipline, and when each patient has a treatment recommendation made by multidisciplinary input. When discussing the need for a new textbook the authors recognized and agreed that critical developments have been transforming the field of head and neck oncology. Indeed, in the past few years there have been significant advances in our understanding of the molecular biology, immune evasion, and genetic landscape of head and neck cancers, as well as the multidisciplinary management of these malignancies, including immunotherapy, targeted therapies, precision radiation therapy, robotic surgery, and supportive care capabilities. With the rising epidemic of human papillomavirus-associated oropharyngeal cancer, customizing treatment is of utmost importance, in particular taking into consideration long-term treatment effects. This book captures key advances and aims to become a quick and handy reference tool for head and neck cancer management issues, and features didactic patient cases in each site-specific management chapter. The authors anticipate that physicians involved in the care of these patients will find the material relevant to their clinical practice. Evidence-based approaches are emphasized throughout the textbook. The book consists of four sections. The first section discusses epidemiology, biology, diagnosis, and staging. The second section deals with established and emerging treatment modalities of head and neck cancers. The third section discusses site-specific management. The fourth section deals with recurrent or metastatic disease and the last section discusses supportive care and special patient groups.

This book serves as a practical and useful guide for the multidisciplinary management of long-term cancer survivors. It consists of 16 chapters that are organized into two sections. Section 1: Foundations of cancer survivorship care covers basic principles of survivorship that aids the clinician in the assessment and management of survivors' care. Chapters 1 and 2 introduce the reader to core concepts of survivorship; provides a review of the Institute of Medicine core domains; and present a definition of cancer survivorship and long-term cancer survivors. Chapter 3 provides a detailed discussion of the basic concepts of surveillance, late effects, and prevention of new or secondary cancers. Chapter 4 outlines the psychologic challenges that often accompany the survivorship experience. Strategies for cancer screening and prevention are discussed in Chapter 5 with application to the needs of long-term cancer survivors. Chapters 6 and 7 focus on the complex care of older survivors, ≥ 65 years and provides a useful discussion of late effects and comorbid conditions which create a confluence of special needs for this population. Chapter 8 discusses the role of integrative medicine in addressing some of the late effects of cancer and its treatment. The book is designed for care of the adult survivors; however, Chapter 9 addresses the burdens faced by adolescent and young adults who are survivors of cancer. Section 2: survivorship care and management for selected disease sites focuses on cancers selected by editors because they were the sites with the largest number of survivors seen in the clinics or are considered the most common in long-term survivors. Chapters 10 to 16 offer guidance on surveillance, prevention, late effects, and psychosocial issues encountered by cancer survivors. Brief clinical vignettes illustrate the application of the clinical practice algorithm(s) and survivorship care plan developed for each type of cancer.