This book details the technical aspects of how to achieve requirements for clinical treatment planning aspects, including patient positioning, creation of patient specific bolus, beam angle configurations, and inverse planning optimization approaches. It is written for everyone involved in treatment planning including dosimetrists, physicists, and physicians. The book comprises of 14 chapters. The first three chapters are introductory chapters. Chapter one describes the types of treatment plans and the general process of treatment planning. The second chapter explains the principles and limitations of current inverse planning optimization algorithms, and discusses the application of auto-planning, knowledge-based planning, and multi-criteria optimization to overcome these limitations. The third chapter covers the available immobilization equipment and general principles of simulation, including patient safety procedures. Chapters four through eleven are organized by body site or system and covers central nervous system, head and neck, breast cancer, thoracic cancer, gastrointestinal radiotherapy, genitourinary cancer, gynecologic cancer, lymphoma, and soft tissue sarcoma. For each site, there is a description of patient simulation, including immobilization, setup, isocenter placement, and any special considerations such as motion management. The plan goals for each treatment site are tabulated, followed by recipes to achieve them from the simplest planning technique to the most advanced planning technique. For simple 3D conformal plans, the recipes include the field arrangement and portal shape design (both with many figures), beam weighting, and selection of dose normalization point. For advanced techniques such as intensity-modulated radiation therapy, volumetric modulated radiation therapy, and stereotactic body radiation therapy, the recipes provide details of creation of optimization structures and multiple stage optimizations. Each chapter concludes with plan evaluation, comparing achieved doses to the clinical planning goals. Chapter thirteen describes treatment planning for pediatric cancers. Chapter fourteen discusses treatment planning for palliative treatment.

This book provides a state-of-the-art overview of the principles of cancer care and best practices for restoring function and quality of life to cancer survivors. Cancer rehabilitation interventions including physical, occupational, or speech therapy; exercise training; psychosocial and cognitive interventions; and physician-directed diagnostic imaging, injections, and pharmacologic symptom management have the potential to treat many impairments from cancer treatment, thereby improving functioning and quality of life. Multimodal rehabilitation interventions have also been shown to improve return to work compared to usual care. The chapters of the book review the latest evidence about which interventions should be used to treat specific impairments thereby constituting the most comprehensive and up-to-date reference on this topic. The book is organized into nine parts comprising 90 chapters. Part one presents history of cancer rehabilitation, cancer statistics, and principles of cancer care. Part two discusses various cancer types, which includes breast cancer, gastrointestinal malignancies, head and neck cancer, pediatric cancers, and primary bone tumors and their assessment and management. Parts three through six describe cancer pain, medical complications, neurological and neuromuscular complications, and musculoskeletal complications of cancer such as radiculopathy, plexopathy, autonomic dysfunction, and bone metastases and their management. Part seven discusses general topics related to cancer rehabilitation, which includes physical and occupational therapy, therapeutic modalities in cancer, therapeutic exercise in cancer, nutritional care of the cancer patient, sexuality issues, and distress and other psychiatric considerations in cancer rehabilitation. Part eight thoroughly explores the identification, evaluation, and treatment of specific impairments and disabilities that result from cancer and the treatment of cancer such as balance and gait dysfunction, cancer related fatigue, radiation fibrosis syndrome, and bowel dysfunction. Part nine discusses functional measurement in patients with cancer, health maintenance and screening in cancer survivors, research issues, barriers to accessing cancer rehabilitation, and building a cancer rehabilitation program.

This book presents readers with the essential aspects of the subspecialty infectious diseases. The second edition of the book includes new developments that are consistent with the published peer-reviewed medical literature and published relevant clinical practice guidelines. The book’s intended audiences are students and medical providers in training. It provides information evolved from prior formal didactic lectures or bedside clinical teaching on clinical infectious diseases, microbiology, and antimicrobial pharmacology that was delivered to help students, residents, fellows, and primary care physicians. Current basic science and clinical concepts regarding each relevant infectious disease topic are still written as a synoptic account to make these topics clear and practical for the readers. The book is organized into 18 parts containing 52 chapters. It adheres wherever possible to a standard pattern of description that aims to define the topic and provide an introduction that would include classification, pathophysiology, and epidemiologic information. The book also lists relevant causative microorganisms; describe the clinical aspects and approach to the topic with the physical examination and relevant laboratory methods, diagnostic imaging, and appropriate antimicrobial therapy. The first part provides introduction to clinical reasoning, antimicrobial stewardship, antimicrobial agents, and medical microbiology. The remaining parts describes the approach to various topics such as: fever of unknown origin, leukocytosis, bloodstream and cardiovascular infections, pulmonary infections, gastrointestinal infections, hepatobiliary infections, hepatic infections, renal–urinary infections, neurological infections, orthopedic-related infections, skin and soft-tissue infections, sexually transmitted infections, infections related to obstetrics and gynecology, eye infections, sepsis, transplant-related infections, ectoparasite-related infections, and infection control and epidemiology. The book’s goal is to help guide the reader through the diagnostic evaluation as well as the process of caring for the patient with an infection.

This book covers all dimensions of palliative care but with a special emphasis on primary palliative care. The book is organized into three parts comprising twenty two chapters. Part one provides the essential background and principles of supportive oncology and palliative care, including chapters on understanding the adult and pediatric patient and family illness experience, the roles and responsibilities of the palliative care team, and the art of the palliative care assessment interview. Part two covers symptom management and includes ten chapters considering the major physical and psychosocial symptoms a cancer patient may face—neurologic, cardiac, respiratory, gastrointestinal, genitourinary, psychiatric, sleep and fatigue, pain, and psychosocial and spiritual distress. Part three addresses special considerations and issues that an oncologist, physician, nurse or other healthcare provider often face in these settings, including chapters on intimacy, sexuality, and fertility issues, grief and bereavement, running a family meeting, care for the caregiver, and survivorship.

This book concentrates on board-related concepts in the field of Rehabilitation Medicine. It will appeal to medical students, residents, and practicing physiatrists. Residents will find the book essential in preparing for Part I and Part II of the Physical Medicine and Rehabilitation (PM&R) Board Certification because it is one of the only books of its kind with major focus on board-related material giving a synopsis of up-to-date PM&R orthopedic, neurologic, and general medical information all in one place. Over 500 diagrams simplify material that is board pertinent. The topics are divided into major subspecialty areas such as stroke, traumatic brain injury, musculoskeletal medicine, electrodiagnostic medicine, prosthetics and orthotics, spinal cord injuries, physical modalities, pulmonary, cardiac, and cancer rehabilitation, pediatric rehabilitation, and pain medicine. All chapters are authored by physicians with special interests and clinical expertise in the respective subjects. Board pearls are highlighted with an open-book icon throughout the text. These pearls are aimed at stressing the clinical and board-eligible aspects of the topics. The content is modeled after the topic selection of the American Academy of Physical Medicine and Rehabilitation Self-Assessment Examination for Residents (SAE-R) Content Outline. This was done specifically to help all residents, post graduates in yearly preparation and carryover from the SAE preparation to board exam preparation. Practicing physiatrists should also find this book helpful in preparation for the recertifying exam.

The Society for Immunotherapy of Cancer (SITC) has expanded efforts to respond to the exponential growth of educational needs by offering primers at the Annual Meeting, itinerant courses to health care providers domestically and internationally, topical meetings and task forces addressing salient questions related to the field, specifying guidelines for patient toxicity management, policy and quality benchmark development, and informing on other themes as they emerge through the SITC portal. In this context, SITC leadership decided to update, refine, and broaden the legacy established by the first edition of this textbook by providing a second edition that targets primarily young basic and clinical investigators but is informative to as many other constituencies as possible. The new edition of Cancer Immunotherapy Principles and Practice updates chapters of the first edition while introducing new ones to cover emerging concepts. Chapters for textbooks can be painstakingly overbearing, but all contributors managed to complete their part to bring together cutting-edge insights that every translational investigator and practicing clinician needs to know about tumor immunology and immunotherapy. The textbook is divided into five sections: Basic Principles of Tumor Immunology, Cancer Immunotherapy Targets and Classes, Immune Function in Cancer Patients, Disease-Specific Treatments and Outcomes, and Regulatory Aspects of Cancer Immunotherapy. These sections cover the continuum from basic principles to practical and clinically relevant information to allow critical understanding of the development and testing of novel therapeutics, companion diagnostics, and useful biomarkers, and inform about the regulatory processes that support the safe and efficient delivery of immunotherapy to patients with cancer. In addition, the chapter on the history of immunotherapy was not only preserved but updated to honor and recognize those who pioneered and championed the field.

Stereo electroencephalography (EEG) has become the predominant method across the world to invasively explore patients with focal epilepsy who are potential candidates for resective surgery. This required many epilepsy centers to introduce major workflow adaptations, investment in surgical and imaging technologies, and seek training in placement and interpretation of depth electrodes recordings. It became evident that a comprehensive, practical textbook outlining the different steps and nuances of the methodology was missing. This book covers all practical aspects of stereo EEG and is a quintessential staple for anybody learning and working in the field of epilepsy surgery, including adult and pediatric epileptologists and neurophysiologists, functional neurosurgeons, technologists, and trainees in these areas. The book is a complete and practical guide to thinking and doing stereoelectroencephalography (SEEG) which will be a solid reference to practitioners around the world. Almost all chapters feature illustrative cases to explain specific aspects and key concepts of the SEEG methodology. The section covering the practical approach to specific epilepsy syndromes includes voice-over slide presentations demonstrating the process of a systematic patient discussion, hypothesis generation, and electrode planning followed by data interpretation and delineation of surgical resection. The book starts with the historical background and principles of stereo EEG and discusses the role of the noninvasive evaluation and patient selection. It describes technical aspects of electrodes, multimodal data coregistration, and guidelines for invasive monitoring. The book then presents the conceptual framework of stereo EEG followed by surgical aspects of stereo EEG electrode placement covering robotic and frame-based approaches, specific pediatric aspects, and potential complications. It describes data interpretation of physiologic, interictal, and ictal epileptic activity, and outlines conceptual and methodological aspects of electrical stimulation mapping. The book ends with discussing surgical procedures to remove the epileptogenic zone and a review of seizure and cognitive outcome with stereo EEG.

Preparation for board examinations can be a daunting and an overwhelming process for many of us. Trainees are often busy with research projects, manuscripts, and a large clinical volume, making it difficult to find time to study for board examinations. Practicing physicians find it hard to keep up on material needed for board recertification. Questions on the board examinations are drawn from well-established, validated medical literature and widely accepted clinical guidelines. This book provides a comprehensive overview of the field of radiation oncology. The format has been designed to efficiently test and reinforce knowledge of key concepts, critical studies, and major clinical guidelines, with the most important radiation oncology citations included. From trainees preparing for their board exams to practicing physicians looking for a review or preparing for the maintenance of certification exam, whether it be a few minutes between patients or a dedicated study session, the book will an invaluable resource to the radiation oncology community. The book is organized into ten chapters. It covers oncology topics such as head and neck cancers, central nervous system cancers, breast cancer, thoracic cancers, gastrointestinal cancers, genitourinary cancers, gynecologic cancers, lymphomas, soft tissue sarcoma, and pediatric cancers. Each chapter has detailed questions covering natural history, epidemiology, diagnosis, staging, treatment options, and treatment-related side effects all in a newly configured format.

This book serves as a practical and useful guide for the multidisciplinary management of long-term cancer survivors. It consists of 16 chapters that are organized into two sections. Section 1: Foundations of cancer survivorship care covers basic principles of survivorship that aids the clinician in the assessment and management of survivors' care. Chapters 1 and 2 introduce the reader to core concepts of survivorship; provides a review of the Institute of Medicine core domains; and present a definition of cancer survivorship and long-term cancer survivors. Chapter 3 provides a detailed discussion of the basic concepts of surveillance, late effects, and prevention of new or secondary cancers. Chapter 4 outlines the psychologic challenges that often accompany the survivorship experience. Strategies for cancer screening and prevention are discussed in Chapter 5 with application to the needs of long-term cancer survivors. Chapters 6 and 7 focus on the complex care of older survivors, ≥ 65 years and provides a useful discussion of late effects and comorbid conditions which create a confluence of special needs for this population. Chapter 8 discusses the role of integrative medicine in addressing some of the late effects of cancer and its treatment. The book is designed for care of the adult survivors; however, Chapter 9 addresses the burdens faced by adolescent and young adults who are survivors of cancer. Section 2: survivorship care and management for selected disease sites focuses on cancers selected by editors because they were the sites with the largest number of survivors seen in the clinics or are considered the most common in long-term survivors. Chapters 10 to 16 offer guidance on surveillance, prevention, late effects, and psychosocial issues encountered by cancer survivors. Brief clinical vignettes illustrate the application of the clinical practice algorithm(s) and survivorship care plan developed for each type of cancer.

The purpose of this handbook is to create a practical guide for trainees, nurse practitioners, physician assistants, and attending physicians to guide them in the treatment of patients with gastrointestinal cancers. The handbook provides key information on diagnosis and treatment, while highlighting the epidemiology, molecular data, and additionally various multimodality treatment options for a broad array of gastrointestinal cancers. It is concise and easy to read, yet broad and practical in its ability to provide for the needs of the medical professional dealing with gastrointestinal cancers. Unique to the book are “How I Treat” vignettes providing not only standards of care but expert recommendations for approaching tough-to-treat disease sites and, in some cases, rare or uncommon patient scenarios. The book is appropriate for physicians in all specialties as well as primary care physicians and other healthcare professionals who are essential members of any team caring for the patient with gastrointestinal cancer. It begins with the most common of the gastrointestinal cancers, colon and rectal cancer, followed by pancreatic, hepatocellular, esophageal, and gastric cancer, cancer of the bile ducts and gallbladder, and then the more rare and unusual cancers such as gastrointestinal stromal tumors, neuroendocrine tumors, and anal carcinoma. In each of these sections, the authors use evidence-based guidelines for the specific cancer to focus on epidemiology and biologic aspects of the disease, including genetic factors and molecular biology. Chapters also discuss modifiable factors, diagnostic testing, and techniques consisting of the molecular basis of diagnosis and treatment of early and advanced disease, which incorporates the role of surgery, neoadjuvant and adjuvant chemotherapy, radiation therapy, immunotherapy, and biologics and their selection and ablative techniques. The presentation is very helpful and unique in that the authors approach advanced disease as oligometastatic and widely metastatic and account for how these approaches differ.