The intent of this book is to provide useful knowledge and practical applications to ease the work of leading or working in a hospital-based nursing research program. It contains principles that apply to all sizes of hospitals, as well as hospital systems that may be spread out over multiple states or be contained in one area. The book describes how nursing research provides new evidence for nursing practice that improves clinical outcomes, changes the culture of the organization, creates new leadership roles for nurses, offers opportunities for interdisciplinary collaboration, enhances patient safety, improves nurse and patient satisfaction, and leads to positive branding of the hospital and the nursing department. Nursing leadership can create (or support) a vision for nursing research based on the benefits that are central to the hospital’s strategic mission and goals. An essential element of setting the foundation and planning, growing, and nurturing a nursing research program is to demonstrate how the program aligns with the strategic plan (vision, mission, and goals) of nursing. The three foundational elements of strong nursing research programs personnel, intranet resources, and a nursing research department database are interconnected and should be available to the entire nursing department, including non-nurse providers and administrators, because important research questions can come from anyone on the team. The nursing research department database is an electronic system of input and storage of direct and indirect data important to the development, conduct, translation, and dissemination of nursing research.