This book details the technical aspects of how to achieve requirements for clinical treatment planning aspects, including patient positioning, creation of patient specific bolus, beam angle configurations, and inverse planning optimization approaches. It is written for everyone involved in treatment planning including dosimetrists, physicists, and physicians. The book comprises of 14 chapters. The first three chapters are introductory chapters. Chapter one describes the types of treatment plans and the general process of treatment planning. The second chapter explains the principles and limitations of current inverse planning optimization algorithms, and discusses the application of auto-planning, knowledge-based planning, and multi-criteria optimization to overcome these limitations. The third chapter covers the available immobilization equipment and general principles of simulation, including patient safety procedures. Chapters four through eleven are organized by body site or system and covers central nervous system, head and neck, breast cancer, thoracic cancer, gastrointestinal radiotherapy, genitourinary cancer, gynecologic cancer, lymphoma, and soft tissue sarcoma. For each site, there is a description of patient simulation, including immobilization, setup, isocenter placement, and any special considerations such as motion management. The plan goals for each treatment site are tabulated, followed by recipes to achieve them from the simplest planning technique to the most advanced planning technique. For simple 3D conformal plans, the recipes include the field arrangement and portal shape design (both with many figures), beam weighting, and selection of dose normalization point. For advanced techniques such as intensity-modulated radiation therapy, volumetric modulated radiation therapy, and stereotactic body radiation therapy, the recipes provide details of creation of optimization structures and multiple stage optimizations. Each chapter concludes with plan evaluation, comparing achieved doses to the clinical planning goals. Chapter thirteen describes treatment planning for pediatric cancers. Chapter fourteen discusses treatment planning for palliative treatment.

This book provides a state-of-the-art overview of the principles of cancer care and best practices for restoring function and quality of life to cancer survivors. Cancer rehabilitation interventions including physical, occupational, or speech therapy; exercise training; psychosocial and cognitive interventions; and physician-directed diagnostic imaging, injections, and pharmacologic symptom management have the potential to treat many impairments from cancer treatment, thereby improving functioning and quality of life. Multimodal rehabilitation interventions have also been shown to improve return to work compared to usual care. The chapters of the book review the latest evidence about which interventions should be used to treat specific impairments thereby constituting the most comprehensive and up-to-date reference on this topic. The book is organized into nine parts comprising 90 chapters. Part one presents history of cancer rehabilitation, cancer statistics, and principles of cancer care. Part two discusses various cancer types, which includes breast cancer, gastrointestinal malignancies, head and neck cancer, pediatric cancers, and primary bone tumors and their assessment and management. Parts three through six describe cancer pain, medical complications, neurological and neuromuscular complications, and musculoskeletal complications of cancer such as radiculopathy, plexopathy, autonomic dysfunction, and bone metastases and their management. Part seven discusses general topics related to cancer rehabilitation, which includes physical and occupational therapy, therapeutic modalities in cancer, therapeutic exercise in cancer, nutritional care of the cancer patient, sexuality issues, and distress and other psychiatric considerations in cancer rehabilitation. Part eight thoroughly explores the identification, evaluation, and treatment of specific impairments and disabilities that result from cancer and the treatment of cancer such as balance and gait dysfunction, cancer related fatigue, radiation fibrosis syndrome, and bowel dysfunction. Part nine discusses functional measurement in patients with cancer, health maintenance and screening in cancer survivors, research issues, barriers to accessing cancer rehabilitation, and building a cancer rehabilitation program.

This book covers all dimensions of palliative care but with a special emphasis on primary palliative care. The book is organized into three parts comprising twenty two chapters. Part one provides the essential background and principles of supportive oncology and palliative care, including chapters on understanding the adult and pediatric patient and family illness experience, the roles and responsibilities of the palliative care team, and the art of the palliative care assessment interview. Part two covers symptom management and includes ten chapters considering the major physical and psychosocial symptoms a cancer patient may face—neurologic, cardiac, respiratory, gastrointestinal, genitourinary, psychiatric, sleep and fatigue, pain, and psychosocial and spiritual distress. Part three addresses special considerations and issues that an oncologist, physician, nurse or other healthcare provider often face in these settings, including chapters on intimacy, sexuality, and fertility issues, grief and bereavement, running a family meeting, care for the caregiver, and survivorship.

The Society for Immunotherapy of Cancer (SITC) has expanded efforts to respond to the exponential growth of educational needs by offering primers at the Annual Meeting, itinerant courses to health care providers domestically and internationally, topical meetings and task forces addressing salient questions related to the field, specifying guidelines for patient toxicity management, policy and quality benchmark development, and informing on other themes as they emerge through the SITC portal. In this context, SITC leadership decided to update, refine, and broaden the legacy established by the first edition of this textbook by providing a second edition that targets primarily young basic and clinical investigators but is informative to as many other constituencies as possible. The new edition of Cancer Immunotherapy Principles and Practice updates chapters of the first edition while introducing new ones to cover emerging concepts. Chapters for textbooks can be painstakingly overbearing, but all contributors managed to complete their part to bring together cutting-edge insights that every translational investigator and practicing clinician needs to know about tumor immunology and immunotherapy. The textbook is divided into five sections: Basic Principles of Tumor Immunology, Cancer Immunotherapy Targets and Classes, Immune Function in Cancer Patients, Disease-Specific Treatments and Outcomes, and Regulatory Aspects of Cancer Immunotherapy. These sections cover the continuum from basic principles to practical and clinically relevant information to allow critical understanding of the development and testing of novel therapeutics, companion diagnostics, and useful biomarkers, and inform about the regulatory processes that support the safe and efficient delivery of immunotherapy to patients with cancer. In addition, the chapter on the history of immunotherapy was not only preserved but updated to honor and recognize those who pioneered and championed the field.

Preparation for board examinations can be a daunting and an overwhelming process for many of us. Trainees are often busy with research projects, manuscripts, and a large clinical volume, making it difficult to find time to study for board examinations. Practicing physicians find it hard to keep up on material needed for board recertification. Questions on the board examinations are drawn from well-established, validated medical literature and widely accepted clinical guidelines. This book provides a comprehensive overview of the field of radiation oncology. The format has been designed to efficiently test and reinforce knowledge of key concepts, critical studies, and major clinical guidelines, with the most important radiation oncology citations included. From trainees preparing for their board exams to practicing physicians looking for a review or preparing for the maintenance of certification exam, whether it be a few minutes between patients or a dedicated study session, the book will an invaluable resource to the radiation oncology community. The book is organized into ten chapters. It covers oncology topics such as head and neck cancers, central nervous system cancers, breast cancer, thoracic cancers, gastrointestinal cancers, genitourinary cancers, gynecologic cancers, lymphomas, soft tissue sarcoma, and pediatric cancers. Each chapter has detailed questions covering natural history, epidemiology, diagnosis, staging, treatment options, and treatment-related side effects all in a newly configured format.

This book serves as a practical and useful guide for the multidisciplinary management of long-term cancer survivors. It consists of 16 chapters that are organized into two sections. Section 1: Foundations of cancer survivorship care covers basic principles of survivorship that aids the clinician in the assessment and management of survivors' care. Chapters 1 and 2 introduce the reader to core concepts of survivorship; provides a review of the Institute of Medicine core domains; and present a definition of cancer survivorship and long-term cancer survivors. Chapter 3 provides a detailed discussion of the basic concepts of surveillance, late effects, and prevention of new or secondary cancers. Chapter 4 outlines the psychologic challenges that often accompany the survivorship experience. Strategies for cancer screening and prevention are discussed in Chapter 5 with application to the needs of long-term cancer survivors. Chapters 6 and 7 focus on the complex care of older survivors, ≥ 65 years and provides a useful discussion of late effects and comorbid conditions which create a confluence of special needs for this population. Chapter 8 discusses the role of integrative medicine in addressing some of the late effects of cancer and its treatment. The book is designed for care of the adult survivors; however, Chapter 9 addresses the burdens faced by adolescent and young adults who are survivors of cancer. Section 2: survivorship care and management for selected disease sites focuses on cancers selected by editors because they were the sites with the largest number of survivors seen in the clinics or are considered the most common in long-term survivors. Chapters 10 to 16 offer guidance on surveillance, prevention, late effects, and psychosocial issues encountered by cancer survivors. Brief clinical vignettes illustrate the application of the clinical practice algorithm(s) and survivorship care plan developed for each type of cancer.

The purpose of this handbook is to create a practical guide for trainees, nurse practitioners, physician assistants, and attending physicians to guide them in the treatment of patients with gastrointestinal cancers. The handbook provides key information on diagnosis and treatment, while highlighting the epidemiology, molecular data, and additionally various multimodality treatment options for a broad array of gastrointestinal cancers. It is concise and easy to read, yet broad and practical in its ability to provide for the needs of the medical professional dealing with gastrointestinal cancers. Unique to the book are “How I Treat” vignettes providing not only standards of care but expert recommendations for approaching tough-to-treat disease sites and, in some cases, rare or uncommon patient scenarios. The book is appropriate for physicians in all specialties as well as primary care physicians and other healthcare professionals who are essential members of any team caring for the patient with gastrointestinal cancer. It begins with the most common of the gastrointestinal cancers, colon and rectal cancer, followed by pancreatic, hepatocellular, esophageal, and gastric cancer, cancer of the bile ducts and gallbladder, and then the more rare and unusual cancers such as gastrointestinal stromal tumors, neuroendocrine tumors, and anal carcinoma. In each of these sections, the authors use evidence-based guidelines for the specific cancer to focus on epidemiology and biologic aspects of the disease, including genetic factors and molecular biology. Chapters also discuss modifiable factors, diagnostic testing, and techniques consisting of the molecular basis of diagnosis and treatment of early and advanced disease, which incorporates the role of surgery, neoadjuvant and adjuvant chemotherapy, radiation therapy, immunotherapy, and biologics and their selection and ablative techniques. The presentation is very helpful and unique in that the authors approach advanced disease as oligometastatic and widely metastatic and account for how these approaches differ.

The field of stem cell transplantation has evolved dramatically over the past decade. Improvements in supportive care and the use of targeted therapies after transplant to prevent relapse have improved the outcome for patients undergoing autologous transplantation. This modality of therapy remains an important therapeutic option for patients with myeloma and relapsed lymphoma. The limitations of donor availability for allogeneic transplant has been largely eliminated with improved molecular typing for unrelated donors and the increasing use of alternative donor stem cell sources, such as haploidentical donors and umbilical cord blood. The safety of allogeneic transplantation has improved by the routine assessment of a patient’s comorbidities and the tailoring of the transplant intensity to achieve the best outcome. This handbook discusses a number of diseases in detail. The chapters give the reader an increased understanding of the disease and the options for therapy. It also allows the reader to understand the role of either transplantation or cellular therapy in the context of disease risk and other therapeutic options. The handbook provides a resource to clinicians caring for patients undergoing transplantation or receiving cellular therapies. Fellows, interns, residents, students, advanced practice professionals in nursing and physician assistants, and pharmacists, as well as others in the care of these patients, may find this handbook useful. The book describes the role of transplantation or cellular therapies in a variety of hematologic malignancies. There are chapters addressing complications related to infections, liver dysfunction, renal dysfunction and pulmonary complications. Special emphasis is given to both acute and chronic graft-versus-host disease and their management. Finally, there is an important chapter on the long-term management of patients after transplantation, which should be of help to all providers who care for survivors of transplantation.

This revised and updated second edition of Handbook of Hematologic Malignancies continues to be an essential and “go-to” resource for the busy hematologist, hematologic oncologist, hematopathologist, oncology advanced practice provider, oncology nurse, and trainee. Hematologic malignancies and their treatment have witnessed many changes in this past decade. Innovations from improved diagnostics to therapeutics have reshaped the ways in which these diseases are characterized and managed. This book highlights critical differential diagnoses to consider as well as provides the most current prognostication tables for each disease in order to facilitate direct extension of this information to the patients. In addition, it includes full-color pathology images that have been selected for their exceptional clarity to help the reader elucidate subtle morphologic differences between disease entities. Concisely organized, each chapter provides the most current, need-to-know points of diagnosis, prognosis, therapeutic management, and clinical trial opportunities for each hematological malignancy. The authors have created relevant clinical cases not only in the book but also in accessible online cases, supporting each chapter with corresponding questions to highlight important deliverables from every chapter. The book provides evidence-based algorithms guiding treatment recommendations for both frontline and salvage settings, with key references supporting each recommendation. The authors’ intention was to create a reference textbook that is concise and easy to read, serving the needs of the medical professional dealing with hematologic malignancies. They highlight current clinical trials that may alter our future practice decisions. Notably, in this 2nd edition, they not only provide major updates and insight into future practice-changing clinical trials but add numerous chapters, particularly those focused on novel cellular immunotherapy, which has been the most exciting revolution in the clinical care of patients with hematologic malignancies.

This book provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon malignancies. Each chapter contains visually engaging figures detailing the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic, and molecular properties of the various agents, and their mechanisms of action. As the first illustrated book of its kind, this highly visual text uses a uniform approach to each cancer drug class and agent presented in the book, and covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Flow diagrams, clinical tables, and bulleted text further explain important information pertaining to each cancer drug class including their indications, mechanisms of action, potential adverse reactions, dosing and dose adjustments, and safety monitoring.