Antipsychotic drugs work by producing indifference and apathy without any specific effect on psychotic symptoms. The antipsychotic drugs have many short-term adverse effects that may lead the clinician, patient, or family to consider medication reduction or withdrawal, including Parkinsonism, dystonias, akathisia, sedation, and apathy. Tardive dyskinesia-often called TD-is a movement disorder caused by antipsychotic drugs that can impair any muscle functions that are partially or wholly under voluntary control, such as the face, eyes, tongue, neck, back, abdomen, extremities, diaphragm and respiration, swallowing reflex, and vocal cords and voice control. Antipsychotic drugs, including the newer ones, can cause neuroleptic malignant syndrome (NMS), which can be fatal in 20” of untreated cases. Long-term exposure to any antipsychotic drug carries severe risks, and a plan for eventual withdrawal should always be part of the treatment. Patients on antipsychotic drugs should be regularly evaluated and physically examined for symptoms of TD.