This chapter continues to delve into specific strategies and considerations for writing different sections of the narrative of the proposal. The chapter uses the National Institutes of Health as the model. It examines the approach, or how the investigator will go about answering the research questions or addressing the aims while conducting the research study or project. The approach section describes in sufficient detail the strategies that will be implemented to achieve the aim(s) of the study. This should include an unbiased approach in the design, recruitment of participants, procedures and measures, human subjects (if relevant), timeline, analysis, interpretation, and reporting of results. When writing the narrative for this section, it is important to consider the lens of reviewers. Lastly, the chapter describes writing considerations for specific types of research designs that are commonly used by health professionals: the randomized clinical trial, the pragmatic clinical trial, community-based participatory research, and mixed method designs.