This chapter reviews the various neurological conditions that a nurse might encounter in the medical–surgical setting. This quick review serves as a refresher for nurses who are preparing for their certification examination. It presents an overview of the condition, signs and symptoms, diagnosis, treatment, nursing interventions, and patient education of the following neurological disorders: Alzheimer’s disease, anxiety, brain tumors, delirium, dementia, depression, encephalitis, Guillain–Barré syndrome, increased intracranial pressure, meningitis, multiple sclerosis, and myasthenia gravis. The chapter discusses Parkinson’s disease; seizure disorders, spinal cord injury, stroke, transient ischemic attack, and traumatic brain injury. It then tabulates the types of seizures with varying symptoms and showcases special features such as complications, nursing pearls, alerts, and pop quizzes to highlight important information on neurological disorders. The chapter concludes with an appendix covering indications, mechanism of action, contraindications, precautions, and adverse effects of various medications used in the treatment of neurological conditions.