This chapter discusses the components and function of the mental status examination, biopsychosocial responses to illness and disability, and biopsychosocial factors related to mental health. It explores the indicators of mental and emotional illness throughout the lifespan, symptoms of neurologic and organic disorders, the dynamics and effects of loss, separation, and grief, and the impact of physical and mental illness on family dynamics. The chapter then describes the indicators of behavioral dysfunction and of traumatic stress and violence, the effects of life events, stressors, and crises on individuals, families, groups, organizations, and communities, and the indicators and risk factors of the client's/client system's danger to self and others. It discusses the effects of physical, sexual, and psychological abuse on individuals, families, groups, organizations, and communities, the characteristics of perpetrators of abuse, neglect, and exploitation, and common psychotropic and non-psychotropic prescriptions and over-the-counter medications and their side effects.