This chapter reviews frameworks for interdisciplinary research, follow them with specific case studies outlining some of the challenges and opportunities of such work, and close with principles of interprofessional research in the global context, with lessons for nursing in particular. It concentrates on interprofessional research capacity-building issues and examples, rather than interprofessional education or clinical practice. Although those are related and integral elements are needed to achieve optimal health for individuals, communities, and populations, the chapter emphasizes research because of its role in creating the evidence that helps improve health. Interprofessional research frameworks have received less emphasis than interprofessional education frameworks that have been developed by different groups, including the World Health Organization (WHO). The WHO has outlined principles to consider when conducting global health research. The chapter demonstrates communication is a fundamental part of the entire research process, especially in the context of multidisciplinary work.