This chapter introduces the concept of attitude, discusses the power it can have on the quality of care, work life, and workplace relationships, and provides tips for influencing positive change. Negative attitudes may be a by-product of change in the workplace and reflect what is really happening at a deeper level with respect to staff’s feelings, perceptions, and behaviors. Most often, such attitudes emanate from feelings of low self-esteem, powerlessness, low level of trust, a sense of betrayal, disrespect, mental and physical exhaustion, and mismanagement. More recently, compassion fatigue has surfaced as potential cause for negativity at work. Change comes in the form of a staff attitude menu with choices that include the good to great, the okay and so-so, and the downright ugly. Nurse managers are ultimately responsible and accountable for ensuring that staff behaviors are consistent with professionalism in practice.