The physical assessment of the pediatric obese patient is similar, yet different, to that of an adult obese patient. It is important to include family in the interview and assessment, as the goal needs to be a collaborative effort for evaluation, assessment, and treatment. Similar to an adult assessment, key skills, including critical thinking, scientific knowledge bases, experience, clinical competencies, attitude, and standard of care, need to be utilized. The health history should be taken directly from the patient and a family member. It is important to use any previous medical records for a complete review. A physical examination should start with the head and progress downward to the toe. Variations in the obese pediatric patient’s physical examination can be seen in multiple areas. Pediatric variations also need to be considered in physical examination. Differential diagnoses should be considered with pediatric obesity. This includes hypothyroidism, Down syndrome, or Prader-Willi syndrome.