The U.S. Citizenship and Immigration Services (USCIS; 2016c) under the U.S. Department of Homeland Security delineates the complex law and path to citizenship as it relates to immigrants, refugees, and asylum seekers. The etiology of the worldwide epidemic of immigrants, refugees, and asylum seekers is clear. It is war that is at the foundation of all human suffering as millions are forced to relocate geographically. This epidemic of person-made disaster points to the overall lack of respect and empathy for human life perpetrated by brutal governments, religious zealots, and other indigenous tribal warring groups. Disaster mental health responders who commit to work with specific indigenous populations of global cultures require a much different approach to provide culturally sensitive interventions and strategies. This chapter offers some guidelines to mental health professionals to begin working globally with the new culture of immigrants, refugees, and asylum seekers.