In developing a research, training, demonstration, or education grant proposal, an important consideration is the structure of the project. Understanding the available options and the nuances of different project structures is helpful and enhances work efficiency, the competitiveness of an application, and the ease with which the project can be implemented. This chapter introduces four models (individual, consultative, cooperative, and collaborative) and discusses the relative merits, characteristics, and considerations of each. An individual model reflects the traditional academic approach. A consultative model is an extension of the individual approach and includes assistance from experts or consultants. Cooperative models can involve either a main investigator who invites individuals at the same institution to work on aspects of the same project or an arrangement among two or more institutions. A collaborative model builds upon a cooperative approach and involves a more complex organizational structure. The chapter will help the reader determine which model is most appropriate for the reader’s proposed project.