This chapter proposes that mindful compassionate coaching (MCC), an approach underpinned by mindfulness, compassion, and body wisdom, is just what is needed to support individuals, teams, organizations, and society as a whole to not only cope, but to thrive and flourish in this volatile, uncertain, complex, and ambiguous (VUCA) world. It discusses some relevant research, principles, behaviors, and practices for MCC, building on previous work, grounded in awareness, and compassion. MCC offers a safe, gentle, yet powerful way to coach, promoting mental and physical well-being, enhancing emotional intelligence, creativity, cognitive functioning, compassion for self and others, and wisdom, all of which are particularly relevant in VUCA world. It can support individuals, teams, organizations, and society as a whole, to turn toward and transform difficulties, including overarching crises for humanity such as excessive consumption, and unethical behavior, ultimately promoting a sustainable collective response to our pressing challenges.