This chapter reviews the anatomy, physiology, and function of skin, hair, and nails and the role skin plays in an individual’s life. Age-related changes in each of these entities along with selected disorders including xerosis; rashes, senile purpura, pruritus, solar elastosis, keratosis, psoriasis, skin tags, herpes zoster, pressure ulcers, and skin cancer are discussed. Lastly, there are recommendations on how to maintain healthy skin and prevent skin cancer.