This chapter discusses the various medical problems associated with obesity among children and adults, as well as the long-term medical consequences of obesity. Throughout the history of mankind, various methods of addressing obesity have been documented. Physicians began to recognize the association between obesity and various other disorders or conditions, including shortness of breath, diabetes, coronary heart disease (CHD), lethargy, depression, ulcers, sleep apnea, and poor circulation. The link between obesity and related diseases and risk factors, however, is not wholly consistent across the life span. Longitudinal studies have found that obesity is related to heightened risk of CHD, heart attacks, and cardiovascular disease mortality in older men, but not necessarily in older women. Childhood obesity is also associated with increased risk of CHD in adulthood. Obese children's risk of hypertension is three times higher when compared with normal-weight peers regardless of race, gender, and age.