The first experiences of supportive and social units come, most often, from the family. This chapter discusses the impact of disability on family by examining the reactions of family members to disability, factors that influence adjustment to disability in the family, adjustment models, parenting reaction perspectives, effective family coping, the impact of disability based on the family role of the person with a disability, and cultural influence on family adaptation to disability. It is important to assess family needs and support services so that the family does not become overwhelmed or feel isolated in their endeavors to assist their loved one and to integrate into the larger community. This involves understanding numerous differences in family reactions and functioning based on the resilience of the family, who in the family has the disability, the extent of the disability, the resources available, and cultural beliefs and practices.