Autism spectrum disorder (ASD) is a range of complex neurodevelopmental disorders characterized by deficits in social development, communication, repetitive behaviors and/or interests, and, in some cases, cognitive delays. This chapter proposes that educators should build an approach that uses a combination of evidence-based practices when designing and implementing interventions for students with ASD. It is important to note that interventions for students with ASD include each of the following strategies: individualized instruction that incorporates choice and preference; functional programming; systemic instruction provided within a structured environment; and collaboration with families. Such programming should steadily expose students with ASD to cues, prompts, and interesting and motivating stimuli, as well as employ consistent feedback and repeated exposure in order to be most effective. The family members of a student diagnosed with ASD most often has the most insight into their child’s needs, styles, strengths, and interests.