Women may seek care for a range of common gynecologic concerns, including menstrual disorders, sexually transmitted infections, vaginosis and vaginitis, sexual dysfunction, contraception, preconception, perimenopause and menopause, and breast or cervical abnormalities. Women also seek care and assistance when they are faced with sex- and gender-specific primary health care issues, such as substance abuse, physical or sexual violence, weight management, osteoporosis, and genitourinary tract conditions. This chapter focuses on the following substance abuse: opioids, alcohol, and tobacco. It reflects specific issues faced by women with addiction. The chapter then discusses definition, etiology, barriers to treatment, history, physical examination, laboratory testing to consider, differential diagnoses, treatment, complications, consulation/referral, and follow-up.