Cancer is considered a “treacherous and uncontrollable invading, transforming and lethal process”. On the psychological level, it can generate a sense of vulnerability, loss of control and hopelessness, emotional lability characterized by a high level of arousal, intrusive thoughts that interfere with normal functioning, and avoidant behaviors in everyday life. Eye movement desensitization and reprocessing (EMDR) has been added to possible treatment methods for patients suffering from cancer. This chapter discusses EMDR in psycho-oncology. There are 8 phases in EMDR: history taking, preparation, assessment, desensitization, installation of the positive cognition, body scan, closure, and reevaluation. EMDR can address the following: multiple cancer-related factors; past traumatic events; coping-skills reinforcement; strengthening resources for the future; and restructuring cognitive, emotional, and behavioral maladaptive schemas that can lead to a more adaptive response. This scripted protocol-based treatment model can be efficiently applied to support patients, their families, and professional caregivers.