Although nurses, other clinicians, and healthcare leaders take great care of others, they often do not prioritize their own self-care. This chapter describes the nine dimensions of wellness and highlights strategies to enhance self-care for optimal health and well-being. The nine dimensions of wellness include: physical wellness, emotional wellness, financial wellness, intellectual wellness, career wellness, social wellness, creative wellness, environmental wellness, and spiritual wellness. Taking time each day to monitor and attend to our own well-being can have multiple rewards for us, from physical to emotional and financial health and well-being. Steps taken today to safeguard and improve one’s own well-being can lead one on a journey to optimal health, well-being, self-discovery, connectedness, and satisfaction. Great leaders engage in good self-care and model wellness behaviors for others. They also see to it that their workplaces encourage and provide resources for their employees’ well-being.