This book highlights how nurses have held a myriad of roles as leaders since the time of Florence Nightingale. Schools of nursing developed master's-prepared nursing programs, which led to the development of advanced practice registered nursing (APRN) roles. Graduate nursing education for nurse leaders has evolved to address the advanced knowledge and skills required in these roles. The book has been developed to be a resource for clinical nurse leader (CNL) and other Nurse Leadership Programs. The intent is to provide a book for faculty and students that focuses on the essential knowledge required in any graduate nurse leader role and in any setting. All graduate level nurses should be prepared to embrace leadership and have a positive impact on healthcare and patient outcomes. The book is organized into three sections comprising 26 chapters. Section I, Nursing Leadership, describes trends in leadership; leadership types; healthcare advocacy; CNL role; lateral integration of care services; integrating the CNL/APRN skill set as master'-prepared nurse leaders; and ethical nurse leadership. Section II, Patient Assessment and Clinical Outcomes, discusses advanced patient assessment; illness/disease management; health promotion, disease prevention, and injury reduction; interprofessional communication and collaboration skills; and health policy, laws, and regulatory issues. Section III, The Care Environment, covers a wide range of topic, which includes healthcare systems and organizational structure; healthcare economics essentials for the nursing professional; financial and budget principles for nurse leaders; knowledge and outcomes management; evidence-based practice; evaluating statistical approaches in nursing; quality improvement and patient safety; and healthcare informatics. Each chapter provides an overview of the topic and how it applies to master’s-prepared nurse leaders. It is hoped that faculty will provide assignments that further clarify how to apply the content to a nurse leader role. This may include papers, projects, in person or online discussions, presentations, and internships.