This chapter provides a brief history of suicide, describes the dimensions of the problem internationally and in the United States, and highlights approaches designed to aid in understanding, preventing, and intervening in suicidal behavior. The ways in which societies have reacted to self-killing has changed across times and cultures. In the United States, the first suicide prevention center was established in Los Angeles in 1958 with a 5-year grant from the U.S. Public Health Service. The center had three major goals: to save lives, to serve as a major public health agency for the community, and to carry out research on suicide. The most common treatment of overtly suicidal people in the recent past has been to treat them with antidepressants with or without talk therapy. It is much more powerful to consider cases holistically by exploring with them their current dimensions of environmental, psychological, cognitive, biological, and spiritual thinking.